ExeVir Bio is a clinical stage company harnessing its VHH technology platform to generate robust antiviral therapies providing broad protection against viral infections, including pan-coronaviruses. It is a spin out from VIB, the world class Belgium-based life sciences research institute. ExeVir’s platform is based on the work of and collaboration with Professor Dr. Xavier Saelens and Professor Dr. Nico Callewaert from VIB. Its lead candidate: XVR011 is a single domain-based anti-SARS-CoV-2 antibody (llama-derived VHH-Fc) optimized for stability, safety, broad neutralizing capability and excellent manufacturability. It stops Covid-19 from entering human cells and demonstrates best-in-class potential offering breadth and potency against a range of Coronaviruses (pan-sarbecovirus neutralization). Preclinical data show XVR011 antibody to be effective against SARS-CoV-2, and importantly, its rapidly spreading variants of concern. ExeVir has recently generated data which demonstrate in vitro neutralization activity against SARS-CoV-2 variants of concern Alpha, Betta, Gamma and Delta. ExeV
